It's a tough choice between Slam Dunk and REAL for me, but since Slam Dunk is already leading I'll second the nomination for REAL. It's very unique in that it depicts disabled people. I have a soft spot for the disabled and I really like how Inoue-sensei has depicted them trying to use sports to lead more normal lives. The art is also brilliant and the emotions they convey are very strong. The focus is less on sports than it was with Slam Dunk, but that also makes for a more interesting manga imo.

