A lot of villains enjoy manipulating their victims, and I think what makes Makishima different is that there's most likely a reason behind his actions both in this hunt and his involvement in previous crimes. Perhaps he's simply enjoying toying with people just for the heck of it or maybe there's something greater that he's trying to work towards.
This is what most interests me right now. What does Makashima want, what are his motives? For what purpose has he aided Midou, Ouryou, and Senguuji? And when will he step out from the shadows.
It's scary how Makishima used Yuki (who is simply a friend of a colleague) to get at Kougami. It means that anyone -no matter how far the relation- is up for grabs to be involved in his game.
Makishima surely didn't waste his time. A thorough investigation led him as far as using the friend of his boss just to lure Kougami out. It didn't seem like he's going to kill Yuki soon because with her there he could tie down Kougami with a responsibility, and with the reinforcement coming I think it would be hard for him (and Senguuji) to do anything further. But with the turmoil inside the team, I guess this incident could be quite a stressor for Akane, clouding her PP a bit. It won't be long before Makishima tried to get his hands on the boss directly.