Lone Wolf and Cub
By: Author: KOIKE Kazuo. Artist: KOJIMA Goseki
Genre: Action, Historical, Martial Arts, Mature, Seinen
Original Publisher: Futabasha
Serialized In (magazine):Manga Action (Futabasha)

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In the feudal era of Japan, Ogami Itto is the elite executioner for the Shogun until the ruthless Yagyu clan frames him in an attempt to gain the position. His name dishonored and his wife murdered, Itto and his infant son Daigoro wander Japan as an assassin for hire, named Lone Wolf and Cub. Ultimately, Ogami Itto strives for revenge against the Yagyu clan.

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This is a classic in my opinion, made into movies, countless references in other media as well like Samurai Jack.