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Could it be that Sasuke is legitimately dying (as per Karin's sensing) but cast the 'A point' of Izanami? And he just has to revive somehow to complete the 'B point' of the loop on Madara?
Even if it's not the mechanism that 'takes down' Madara per se, it could legitimately slow him down for some time while the heroes figure out how to-
I MEAN WHILE ZETSU STEALS HIS BODY+JUUBI AND COMPLETES THE FAN-GOSPEL ACCORDING TO ME