If Eyeshield 21 gets another anime seeing as the manga is already finish I don't see any reason why not.
What studio would you like to do it polls above will show which studios I have in mind.
If it does make it a remake and start from the beginning of manga but following the manga's story line more properly EX:Sena and Monta searching for Musashi before the Nasa game and the Ojou-Shinryuji spring match, better color scheme and character design and animation.
There should be no editing on smoking, drinking, gambling because smoking was important for Ha Ha brothers growth and Drinking and Gambling were played for laughs mostly.
The matches make them shorter with no filler moments make it like one episode for lesser matches and two to five episodes for major matches.
There should be no editing of the violence or there is make it less not to ruin it or make it kiddy be which is a problem because of Hiruma's sense of humor and habit, Agon's nature, Gaou's carnage and Zokugaku's foul play.
As for the voices those who remain the same are:
Sena, Hiruma, Monta, Jumonji. Kuroki, Togano, Yukimitsu, Komusubi, Natsuhiko, Musashi, Habashira, Banba, Harao, Kamaguruma, Apollo, Kid, Tetsuma, Kotaro, Akaba, Shin, Sakuraba, Otawara, Takami, Ikari, Marco, Gaou
The new voices are:
Mamori Anezaki-Shizuka Itou
Suzuna Taki-Ami Koshimizu
Patrick Spencer-Suguru Inoue
Jeremy Watt-Hino Shimono
Homer Fitzgerald-Akio Otsuka
Shun Kakei-Tomokazu Seki
Kengo Mizumachi-Kenichi Suzumaru
Riku Kaitanai-Romi Park
Aon Kongo-Nobutoshi Kanna
Unsui Kongo-Toshiyuki Morikawa
Ikkyu Hosokawa-Masakazu Morita
Gondayu Yamabushi-Tetsu Inada
Hiromi Kisaragi-Takehiro Sakurai
Takeru Yamato-Junichi Suwabe
Karin Koizumi-Mamiko Noto
Taka Honjo-Daisuke Namikawa
Kureji Hera-Wataru Takagi
Reisuki Aki-Nobuyuki Hiyama
Clifford D. Louis-Masayaka Onosaka
Bud Walker-Kazuya Nakai
Donald Oberman-Fumihiko Tachiki
Tell me your opinions on this voice cast and if you disagree with the choices or have your own.
For the mini corner use Mamori's diary of bad drawings, Devilbat investigation corner and other gag strips from the manga