Well, looking at the elders lately, physically talking they are not to be underestimated. Plus they have power of number, unlike our dear nobles team or Lukedonia (we only see leaders so far, really, where are the others?!).
Now I have just given this a thought, but.. What is exactly the source of power of these humans? If it's the vampire then we can probably say that it is in their blood to be able to use special power, but humans... Excluding those who made a contract with the traitorous nobles, how did they get such power? Like Crombel, for example. :O