You might be confusing with Roushi, the Yonbi jinchuuriki, who wasn't a perfect either.
right,tsunade's grandmother was mito uzumaki,who was still alive when tsunade was born. kishi may explain her vitality by taking about mito. that prevented her to die and may allow her to avoid dying in next fights.
Even Yamato, although he's said to have ebeen the best ANBU during Sarutobi's last times isn't so big while he's some sort of clone of Hashirama. And karin sucks bad. But she's around genin level so let's take her out of count.
I hope roshi won't end up being an uzumaki. he is too old,and he died quite quickly despite being an uzumaki. so he can't be an uzumaki,especially since his kekkei genkai isn't own of uzumaki and I doubt he could possess both abilities
two branches/cousins of descendants from the same ancestor with slightly different specialities, there is the existant possibility they could combine
i'm damn curious as to what happened to tsunade's parent, and all the other children of hashirama and that uzumaki jinchuuriki
Uzumaki jinchuuriki? Mito? She died after the Kyuubi was extracted from her and put into Kushina, I'm guessing. Or soon after, if she was able to live that long. She lived long enough to meet Kushina at I'm guessing at least the age of 8.
Tsunade is an Uzumaki, she has Uzumaki blood anyway. Probably pretty diluted, but she's part Uzumaki thanks to her grandmother, if not either her parents.
it was a pity we haven't seen tsunade's parents yet,especially since one of them was the son of the 1st hokage,he must have been known,and maybe even stronger than tsunade,although not strong enough to compete with his father. but I think it can't be helped,since we haven't seen sakura's parents either.
we thought so because his mother was an uzumaki (she had got red hair) while his father had black hair. since the rinnegan since to be the sum of uchiha and senju,a lot of people speculated that.
Btw Sakura -is she an uzumaki? Honestly I am not sure if members of uzumaki know about their abilities, like when Karin met Naruto she didn't think about anything like that we from the same clan, maybe she is not aware about the power of Uzumaki?