Actually, and I apologize in advance if this is getting out of hand, since Indra requires you to crush almost all of your hearts, maybe the darkness/mark is built inside those and destroying it like that (as opposed to "just" stabbing a heart) results in an excessive amount of darkness flooding the body and taking control of shit like the vegetative neural system (that what it's called in English? Hope you guys get what I'm talking about lol), making the demons lose themselves and becoming a raging mass of bloodlust that basically attacks anything that moves.
I guess it's a bit hard to explain it logically, since they were basically like "ACCEPT THESE HEARTS AS A SACRIFICE, O DARKNESS!", but we can try. xD
As we know, at least a portion of the darkness circulates in the demons' blood. Once the six hearts are destroyed, the remaining one likely takes all responsibility and acts like "OH NO, I CAN'T PUMP ENOUGH BLOOD! GO, GO, WORK MORE!", and as a result, it starts pumping like crazy, leading to some other organs (darkrenal glands, heh) likely acting the same way, just like when a starving person's liver swells up immensely. As a result of this overworking, an enormous amount of darkness is released, and even the central nervous system is affected by it, leading to an uncontrollable behavior.
At one point, the body can't handle the change anymore and just gives up, leading to death.
Of course, this process has to be triggered by the brain, as it only occurs intentionally. There could be a hormone similar to adrenalin or whatever which leads to that higher-paced working and is somehow willingly. Therefore, in case the six hearts are destroyed without the owner's intention, nothing happens.
This is a manga, though, so it's probably not accurate at all. LOL
But still, this is what this thread is about, so we can speculate all we want.