My guess is its tsunade. Aside from kabuto she's the only one that fits in the longrun story wise. Sasuke's goal is to become hokage and create a village without darkness. What better way than to separate the distinction between senju and uchiha (the long running grudge). Tsunade also has to die...
Re: Nidaime + Mist connection.
His death was never confirmed. He only stayed behind to give the others time to escape. He was only assuming he wouldn't survive. As for revealing his name prior, it makes little difference to my theory. I am under the assumption that the 1st ninja war occured...
Nidaime + Mist connection.
According to the newest chapter the Nidaime's name was tobirama. The Nidaime was a master of water style jutsus and his death was never explained. I'm wondering if he has any connection with the mist village and/or madara. My opinion is the nidaime was the founder of...