#1 Quaetro's gender is never stated, and SIU has specifically mentioned that it will be stated later on. There's a reason why it even has some sort of significance that SIU would comment on it.
#2 Chang has been hiding his true strength. I fully believe he's just capable of hiding who he really...
Chang is not dead.
"True Freedom", actually meant him being released from Yama/FUG's control. Quaetro was the one shot. Chang is the third Mad Dog, and he's now free. Yuri pretty much gave a small hint way back, when she noted he was basically hiding his strength. It's also why he grabbed Angel...