Of course, if you use a plugin for cleaning a volume raw, which is already leveled, you'll get a very sad result.
But please don't misunderstand me, I just said that if you use your brain, you can get a perfect cleaning without using any denoiser. But if you make a speed Edited Manga, obviously...
Yeah, that's right. If you want to make a HQ Edited Manga, you don't need plugins too much.
Besides, if you are a fast-scan group, you should try Topaz Denoise, Topaz Clean or Topaz Vivacity, and Neat Image.
However, those plugins will make the raw look distortioned.