I kinda have this feeling that Inosuke got reincarnated as a botanist man known for his Blue Spider Lily project and his talent for research about the nature and really wasn't Inosuke's direct descendant... But this time, he's matured and all alone. Future Inosuke is like his incarnation Inosuke...
You look like you're in need for a sequel but I kind of object. This series doesn't need a sequel for it's unnecessary.
Maybe Gotouge will continue the Curse Buster boi manga in a few years.
But unfortunately, she perhaps won't pursue her carreer as a mangaka for a few years, and I do hope...