In the chart Biscuit made, E (the weakest guy) has no chance of beating D (the strongest guy) even if D is at his worst and E is at his strongest.
The power of the Ants are off the scale. The difference between even a Royal and humans is far beyond the difference between D and E in that chart, let alone Meryem. Pufu said that there's about a 10% chance Morel could've beaten him if there are several guys as strong as him on the side. You're not anywhere near someone's league if you need several guys as strong as you to just have a slim chance of beating someone when he's already trapped in your ideal terrain. I know later in the Election Arc they made it sound like it's easy to find guys stronger than Morel, despite the fact that his accomplishment in this battle alone may be enough to get him the Triple Star. So really, you need several Triple Star level guys to even have 10% chance of winning and that's reasonable? Especially when it seems certain Pariston and Chidol are much weaker than Morel (Pariston says both he and Chidol lacks strength. Even if he's lying about himself, it can be assumed his assessment on Chidol must be correct).
Likewise Yupi was never in danger of losing until he got infected by plot stupidity, e.g. he purposely killed every clone of Morel's even though he actually know where the real Morel was. He then spared Knuckles even though that wasn't even part of the agreement. Now, to be fair Yupi caught a break too in that Knuckles didn't just wait until he bankrupt when Yupi decided Knuckles was not a threat, though I'm pretty sure if he waited for the normal time to bankrupt it'd have taken so long that it wouldn't have mattered because Pufu would've come back and killed everyone long before Yupi went bankrupt if they didn't try to attack him again.
Of course the whole point of the Ants was that aside from Uber Gon versus Pitou, none of matchups ever had a chance of winning, but if you understand that then why even have the fight? Sure the whole point was that only defeating Meryem matters in the grand scheme of things, but what's the point of a fight that is already doomed to fail?
For the whole empathy thing, Meryem does not have empathy for humans. Even when he's negotiating with Netero it's still about the same as what a negotiation would look like between humans to sentinent cows. He only says the Ants won't kill unnecessarily, but he says humans are no longer necessary in the evolutionary chain, so the only purpose left is:
1. Serve as food for Ants.
2. The rare special humans, like Komugi or Netero, may have a place in this new world, but only very few people would qualify.
The absolute best case would be if all the excess humans gets locked up in a zoo or something and just spend whole day locked up. Since Meryem sees no value in an ordinary human, you'd expect after a while humans will only be born to be for food sort of like how chickens/cows/pigs are only raised for food, and any occasional special human gets to escape an ugly fate. After all, why would Meryem want to waste resources feeding a bunch of normal humans if he has no interest in killing humans for fun? In fact more humans are likely to survive overall if Meryem was a tyrant, because then at least he'd have to raise a lot of humans so he can kill them later.
If there are sentinent cows they'd rightfully see humans as some kind of crazy genocidal maniacs. It doesn't matter there are some vegetarians out there and that some cows get on special animal shows or whatever. From the viewpoint of cows, human must embody evil and any negotiation with them would be impossible. This is what should happen in the humans to Ants negotiation, only the roles are reversed. You can't negotiate with a race whose leader sees your race's sole purpose for existence as food, minus an occasional super special guy that'd be equivalent of an animal show star.