I agree, draw the way you feel better... If you don't have any restrictions to your work (like japanese manga is commonly read from right to left), you can go either way, so it would depend on who you would be targeting, like Utsune said...
The way characters appear in the panels you might need to be more careful, like, two characters that are in a conversation, it's better to have them "facing" each other even on separate panels... The first one looks to the right, the other to the left, for example... it helps with continuity
good luck with your work
