There are many hints that Zoro may clash with Kaido. Zoro already killed a dragon in Punk Hazzard, Ryuma has slain a dragon (it may end up being Kaido's wound), Zoro is often regarded as a wild beast and many are of the opinion that he is a tiger which is a mortal enemy of a dragon in Chinese mythology.
Considering that Kaido has been defeated 7 times and "attended" numerous executions and suicides he only seems to have one single wound. This will probably play a crucial role for his defeat as it seems that he is basically invulnerable so finding out how he received that wound may give our protagonists a chance to critically injure him.
If it turns out that that wound comes from Ryuma then its pretty much clear that it has to be Zoro to inflict it again, as i simply dont see anyone in Wano who is better in swordsmanship than Zoro. Still, the gap in strength is far too big and Zoro cant just take Kaido on, no one can, so it will be interesting to see how it will play out and give Zoro a chance to inflict a final blow.