Count me in the group who hopes for a big serialisation round (4+ series) after the double issues and One Piece's 1,000th chapter celebration. Blue Box is sure to get a serialisation eventually, though maybe not this soon in the year. My prediction however is there will be a couple of sports manga as a build up to the Summer Olympics.
In terms of the current state of the magazine and what's in danger, I'd say:
Secured:
1. One Piece - One Piece
2. My Hero Academia - Pillar of the magazine
3. Jujutsu Kaisen - Soon to be/already is a pillar of the magazine
4. Dr. Stone - Pretty consistent with great TOC rankings.
5. Black Clover - Already peaked but still stable.
6. Mashle - Early success story.
7. Undead Unluck - Early success story.
8. Ayakashi Triangle - Solid sales for a returning/veteran mangaka; fills the ecchi slot in the magazine.
Safe, partially due to the lack of veterans in the magazine:
9. Mission: Yozakura Family - Sales slightly improving, TOC rankings definitely improved.
10: Me & Roboco - Fine sales for V1, very good/great TOC rankings.
11. Magu-chan: God of Destruction - Fine sales for V1, showing possible improvement in the TOC.
12. Hard-Boiled Cop and Dolphin - Fine sales for V1 though underwhelming for a returning/semi-veteran mangaka.
Uncertain, time will tell:
13. Phantom Seer - The rankings have not been good, volume 1 sales will help give a clearer idea.
14. High School Family: Kokosei Kazoku - Tricky to predict whether it's finding its place near the end of the magazine or just not popular.
Likely, needs to improve:
15. Agravity Boys - It can only dodge the bullet so many times, and now the story seems to be slowly approaching endgame stages.
16. Our Blood Oath - Has done straight to the bottom and will likely stay there unless it somehow gains buzz (which I doubt).
Definitely ending
17. Moriking - Everything points to it concluding within a matter of weeks.
18. Chainsaw Man - In its final climax; I reckon within single digits, could end just after We Never Learn.
19. We Never Learn - Likely 3 chapters left, ending #2 unless it has an epilogue chapter.
Too soon:
20. Build King - Too early and editorial push incoming...
21. Sakamoto Days - Too early